Function
Regulating qi and strengthening spleen, drying dampness and resolving phlegm.

indications
1. Syndrome of qi stagnation in spleen and stomach: This product has the functions of activating qi and relieving pain, invigorating spleen and middle energy. Because of its bitterness, warmth and dryness, qi stagnation in cold and dampness is the most appropriate.
2. Vomiting and hiccup: tangerine peel is fragrant and fragrant. It is good at dredging qi and adjusting medium coke to make it rise and fall orderly.
3, wet phlegm, cold phlegm cough: this product can not only dry dampness phlegm, but also warm cold phlegm, and pungent line bitter discharge and can promote lung cough, for the treatment of phlegm to medicine.
4. Thoracic arthralgia: This product can relieve pain through warming, entering the lung and walking the chest, and can relieve pain through qi.

Usage and dosage
Internal administration: decoction, 3-10g; Or into pills, powder.

Taboo
1, Chinese and Western medicine incompatibility:

(1) It is not suitable to be used with monoamine oxidase inhibitors such as furazolidone, which will cause "amine toxicity reaction".
(2) should not be used with phentolamine, tolazolin, phenoxybenzamine and other alpha receptor blockers, these drugs will block the role of tangerine peel boost.
(3) should not be used with digitalis and other cardiac glycosides, can enhance the role and toxicity of cardiac glycosides.
(4) should not be used with some western medicine preparations such as calcium carbonate, magnesium sulfate, ferrous sulfate, aluminum hydroxide, bismuth carbonate, etc. The flavonoids in tangerine peel can form complexes with these drugs to affect drug absorption.

2. Dietary taboos: Avoid food that is cold, sticky and easy to produce phlegm.

Precautions
Qi deficiency syndrome, yin deficiency dry cough, vomiting blood syndrome and tongue red less fluid, with real heat in the body.

chemical composition
Pericarpium Citri Reticulatae contains nobilicin, hesperidin, neohesperidin, hesperetin, hydroxyfarin, flavonoids, etc. Pericarpium Citri Reticulatae volatile oil content of 1.5-2.0%, pericarpium Citri Reticulatae volatile oil content of 1.2-3.2%, its components are α-side of the alkene, limonene and so on.

Pharmacological action
The decoction has a direct inhibitory effect on isolated intestines of rabbits and mice, gastric and intestinal motility of anesthetized rabbits and dogs; a small amount of decoction can enhance cardiac contractility, increase cardiac output, dilate coronary arteries, increase coronary flow, and inhibit the heart in large doses; fresh orange peel decoction has the effect of expanding the trachea. Volatile oil has irritating expectorant effect, and the main active ingredient is limonene. Pericarpium Citri Reticulatae Decoction has inhibitory effect on isolated uterus of mice, while high concentration makes it completely relaxed. Intravenous injection of decoction can make anesthetized rabbit uterus tonic contraction. It is beneficial to bile and reduces serum cholesterol.

toxicological effect
50% fresh orange peel decoction 3 ml/kg to the dog stomach, or 50% dry decoction to the animal several times 1 ml/kg intravenous administration, were not acute. Methyl hesperidin pure products to mice intravenous injection, LD50 is 850 mg/kg, but often mixed with toxic hesperidin chalcone derivatives. For example, the LD50 of 3,6-dimethylhesperidin chalcone to mice is 60 mg/kg, which is more toxic. Hesperidin was extracted from orange peel. The methylation of hesperidin extracted with ethanol was lower, and the LD50 of mice was 1200 mg/kg. The methylation of hesperidin extracted from butanol is methyl hesperidin, and its LD50 is 150 mg/kg, which is because the ethanol extractors remove more toxic chalcone.

Related discussion
1. Shen Nong's Materia Herb Sutra: "The main body is hot in the chest, against the qi, benefiting the water valley, taking it for a long time to remove the smell and lower the qi."

2. Compendium of Materia Medica: "Treat nausea, nausea and noise, sometimes spit water, spit phlegm, cough malaria, stool occlusion, women's breast carbuncle. Into food, solution fishy poison." "To cure all kinds of diseases, we should always take the power of rationalizing qi and drying dampness. The same tonic is tonic, the same laxative is diarrhea, the same ascending medicine is ascending, and the same descending medicine is descending."